Hereditary colorectal cancer syndromes and genetic testing

Carole Macaron, Brandie H Leach, Carol A Burke
Journal of Surgical Oncology 2015, 111 (1): 103-11
Colorectal cancer (CRC) is a leading cause of cancer and cancer deaths in the Western world. Approximately 5-10% of CRC are hereditary, due to a defined genetic cause. Individuals and families affected with a hereditary CRC syndrome exhibit benign and malignant extra-intestinal tumors, require aggressive cancer screening and benefit from management by a multi-disciplinary team of professionals. The clinical manifestations, genetic causes and current management of patients with hereditary colon cancer syndrome is provided.

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