Second-generation ALK inhibitors: filling the non "MET" gap

Suresh S Ramalingam, Fadlo R Khuri
Cancer Discovery 2014, 4 (6): 634-6
Ceritinib and other second-generation inhibitors have demonstrated promising anticancer activity in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC). Specifically, they can overcome resistance due to certain gatekeeper mutations acquired following crizotinib exposure. These agents now provide new options for the management of ALK-positive NSCLC.

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