Predictive value of gelsolin for the outcomes of preterm neonates: a pilot study

BACKGROUND: Plasma gelsolin is a circulating actin-binding protein that has a protective role against tissue injuries. Our aim was to compare the baseline levels of gelsolin in premature infants with neonatal outcomes.

METHODS: A total of 32 preterm neonates born at 23-32 weeks of gestation were enrolled in the study.

RESULTS: Plasma gelsolin levels at 72 h were significantly lower in patients with respiratory distress syndrome, in patients who were administered surfactant therapy and in patients who developed sepsis (P < 0.05). Plasma gelsolin levels at 28 days were significantly lower in patients who developed bronchopulmonary dysplasia and retinopathy of prematurity (P < 0.05).

CONCLUSIONS: Low plasma gelsolin levels in the first postnatal month may be associated with poor outcomes in premature infants.