Predictive value of gelsolin for the outcomes of preterm neonates: a pilot study

Mehmet Kose, Tuba Elmas, Selma Gokahmetoglu, Mehmet Adnan Ozturk, Duygu Ekinci, Ferhan Elmali, Hulya Halis, Osman Bastug
Pediatrics International: Official Journal of the Japan Pediatric Society 2014, 56 (6): 856-859

BACKGROUND: Plasma gelsolin is a circulating actin-binding protein that has a protective role against tissue injuries. Our aim was to compare the baseline levels of gelsolin in premature infants with neonatal outcomes.

METHODS: A total of 32 preterm neonates born at 23-32 weeks of gestation were enrolled in the study.

RESULTS: Plasma gelsolin levels at 72 h were significantly lower in patients with respiratory distress syndrome, in patients who were administered surfactant therapy and in patients who developed sepsis (P < 0.05). Plasma gelsolin levels at 28 days were significantly lower in patients who developed bronchopulmonary dysplasia and retinopathy of prematurity (P < 0.05).

CONCLUSIONS: Low plasma gelsolin levels in the first postnatal month may be associated with poor outcomes in premature infants.

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