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Two is better than one: Complementing oncolytic virotherapy with gemcitabine to potentiate antitumor immune responses.
Oncoimmunology 2014 January 2
Oncolytic viruses (OVs) preferentially infect and kill cancer cells. Additionally, OV-induced immune responses subvert cancer-associated immunosuppression and promote antitumor immunity. We have recently demonstrated that the complementation of oncolytic virotherapy with gemcitabine accentuates its immunostimulatory effects, hence exerting superior antineoplastic activity.
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