The CHA2DS2-VASc score as a predictor of left atrial thrombus in patients with non-valvular atrial fibrillation

Omer Uz, Murat Atalay, Mehmet Doğan, Zafer Isilak, Murat Yalcin, Mehmet Uzun, Ejder Kardesoglu, Bekir Sitki Cebeci
Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre 2014, 23 (3): 234-8

OBJECTIVE: To investigate whether or not the CHA2DS2-VASc score predicts left atrial (LA) thrombus detected on pre-cardioversion transoesophageal echocardiography (TEE).

MATERIALS AND METHODS: The medical records of patients who had undergone TEE were reviewed to assess the presence of LA thrombus prior to direct-current cardioversion for atrial fibrillation (AF). The CHA2DS2-VASc score was calculated for each patient. Clinical TEE reports were reviewed for the presence of LA thrombus. Patients with a valve prosthesis or rheumatic mitral valve disease were excluded from this study.

RESULTS: A total of 309 patients were identified. The mean age was 70.1 ± 9.8 years and 151 (49%) patients were males and 158 (51%) were females. LA thrombus was seen in 32 (10.3%) of the 309 patients. Fifty (16.2%) patients had a low CHA2DS2-VASc score (0-1), 230 (74.4%) had an intermediate score (2-4) and 29 (9.4%) had a high score (5-9). The incidence of LA thrombus in the low, intermediate and high CHA2DS2-VASc score groups was 0, 4.4 and 68.7%, respectively. The LA thrombus risk increased with increasing CHA2DS2-VASc scores. On multivariate logistic analysis, the CHA2DS2-VASc score (OR 3.26, 95% CI 2.3-4.65; p = 0.001) and age (OR 0.93, 95% CI 0.88-0.98; p = 0.004) were independent risk factors for LA thrombus in patients with non-valvular AF.

CONCLUSION: A high CHA2DS2-VASc score was independently associated with the presence of LA thrombus in patients with non-valvular AF.

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