Valproate-induced hyperammonemic encephalopathy in a renal transplanted patient

Christina Melexopoulou, Smaragdi Marinaki, Maria Darema, Chrysanthi Skalioti, Athina Efthimiou, George Zavos, John N Boletis
Renal Failure 2014, 36 (6): 955-6
Neurological complications after renal transplantation constitute an important cause of morbidity and mortality. Their differential diagnosis is difficult and essential for subsequent patient's management. Valproate-induced hyperammonemic encephalopathy is an uncommon but serious effect of valproate treatment. Here, we describe the case of a 15-year-old girl who was on a long-term therapy with valproate due to epilepsy and revealed impaired consciousness with hyperammonemia 12 days after renal transplantation. After withdraw of valproate, patients' symptoms resolved within 24 h. Clinicians should increase their awareness for potential complication of valproate, especially in transplanted patients.

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