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RESEARCH SUPPORT, NON-U.S. GOV'T
REVIEW
Hippocampal synaptic plasticity, spatial memory and anxiety.
Nature Reviews. Neuroscience 2014 March
Recent studies using transgenic mice lacking NMDA receptors in the hippocampus challenge the long-standing hypothesis that hippocampal long-term potentiation-like mechanisms underlie the encoding and storage of associative long-term spatial memories. However, it may not be the synaptic plasticity-dependent memory hypothesis that is wrong; instead, it may be the role of the hippocampus that needs to be re-examined. We present an account of hippocampal function that explains its role in both memory and anxiety.
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