JOURNAL ARTICLE
REVIEW

Acute-phase reactants in periodontal disease: current concepts and future implications

Vilasan Archana, Ranjith Ambili, Krishnavilasam Jayakumary Nisha, Abraham Seba, Chandran Preeja
Journal of Investigative and Clinical Dentistry 2015, 6 (2): 108-17
24510428
Periodontal disease has been linked to adverse cardiovascular events by unknown mechanisms. C-reactive protein is a systemic marker released during the acute phase of an inflammatory response and is a prognostic marker for cardiovascular disease, with elevated serum levels being reported during periodontal disease. Studies also reported elevated levels of various other acute-phase reactants in periodontal disease. It has been reported extensively in the literature that treatment of periodontal infections can significantly lower serum levels of C-reactive protein. Therefore, an understanding of the relationship between acute-phase response and the progression of periodontal disease and other systemic health complications would have a profound effect on the periodontal treatment strategies. In view of this fact, the present review highlights an overview of acute-phase reactants and their role in periodontal disease.

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