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Effect of sevoflurane on tissue permeability of lung ischemia-reperfusion injury in rats

Xiao-Hui Li, Zhong-Hua Liu, Hong-Bing Ma, Yong Li, Hui Zhao, Jian-Bo Che, Wei-Chao Liu, Gong-Ning Shi
Asian Pacific Journal of Tropical Medicine 2014, 7 (4): 276-9
24507675

OBJECTIVE: To investigate the effect of sevoflurane on tissue permeability of lung ischemia-reperfusion injury (LIRI) in rats.

METHODS: A total of 45 wistar rats were randomly divided into 3 groups I, II, III. Modified Eppinger method was adopted to establish the rat lung ischemia-reperfusion injury model. Group I served as the control group, group III as ischemia reperfusion group, group III as sevoflurane ischemia-reperfusion group. Blood gas index, lung permeability index (LPI) change, lung tissue pathology change and lung water content were observed and compared between groups of rats at different time points.

RESULTS: During ischemia reperfusion, all rats kept balance of the MAP during different time points, SPO2 of group II and III decreased significantly than I group (P<0.05); after reperfusion lung permeability index in Group II and III was higher than the control group significantly (P<0.05), 120 min after reperfusion LPI change and injury of group III was significantly lower than II group (P<0.05); interstitial and alveolar cavity effusion in of group III were lower than that of group II.

CONCLUSIONS: Sevoflurane pretreatment can reduce the lung tissue permeability, and LIRI plays a protective role in LIRI.

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