Two new neoclerodane diterpenoids from Scutellaria barbata D. Don growing in Vietnam

Do Thi Thao, Do Thi Phuong, Tran Thi Hong Hanh, Nguyen Phuong Thao, Nguyen Xuan Cuong, Nguyen Hoai Nam, Chau Van Minh
Journal of Asian Natural Products Research 2014, 16 (4): 364-9
Various chromatographic separations of the aerial parts of Scutellaria barbata afforded two new neoclerodane diterpenoids, scutebatas S and T (1 and 2), along with scutebata D (3). Their structures were elucidated by spectroscopic methods including high-resolution electrospray ionization mass spectrometry, 1D and 2D NMR and comparison with the literature values. Compounds 1 and 3 exhibited moderate cytotoxic activities against HL-60 (promyeloblast) human cancer cells. Weak cytotoxic effects toward four tested human cancer cell lines including KB (epidermoid carcinoma), LU-1 (lung adenocarcinoma), MCF7 (breast cancer), and Hep-G2 (hepatoma cancer) were observed for 1 and 3; whereas 2 was inactive on all five tested cell lines.

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