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Journal Article
Review
Systematic Review
H2-antihistamines for the treatment of anaphylaxis with and without shock: a systematic review.
Annals of Allergy, Asthma & Immunology 2014 Februrary
BACKGROUND: Anaphylaxis is a serious allergic or hypersensitivity reaction, which is rapid in onset and sometimes can prove fatal. Although H2-antihistamines are often administered for emergency treatment in anaphylaxis, there is uncertainty about their effectiveness in this disease.
OBJECTIVE: To assess the benefits and harms of H2-antihistamines in the treatment of anaphylaxis.
METHODS: A systematic review was performed of randomized controlled trials and quasi-randomized controlled trials comparing H2-antihistamines with placebo or no intervention in patients with anaphylaxis.
RESULTS: The authors failed to identify any eligible studies for inclusion in this systematic review.
CONCLUSION: When H2-antihistamines are recommended for anaphylaxis treatment, the status of the evidence base supporting their use should be described. Well-designed randomized controlled trials investigating the role of H2-antihistamines in anaphylaxis treatment are urgently needed.
OBJECTIVE: To assess the benefits and harms of H2-antihistamines in the treatment of anaphylaxis.
METHODS: A systematic review was performed of randomized controlled trials and quasi-randomized controlled trials comparing H2-antihistamines with placebo or no intervention in patients with anaphylaxis.
RESULTS: The authors failed to identify any eligible studies for inclusion in this systematic review.
CONCLUSION: When H2-antihistamines are recommended for anaphylaxis treatment, the status of the evidence base supporting their use should be described. Well-designed randomized controlled trials investigating the role of H2-antihistamines in anaphylaxis treatment are urgently needed.
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