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JOURNAL ARTICLE

Prognostic significance of Ki-67 in chemotherapy-naive breast cancer patients with 10-year follow-up

Hiroshi Nishimiya, Yoshimasa Kosaka, Keishi Yamashita, Naoko Minatani, Mariko Kikuchi, Akira Ema, Kazunori Nakamura, Mina Waraya, Norihiko Sengoku, Hirokazu Tanino, Masaru Kuranami, Masahiko Watanabe, Watanabe Masahiko
Anticancer Research 2014, 34 (1): 259-68
24403472

BACKGROUND/AIM: In order to define accurate survival outcome in breast cancer, 10-year follow-up is required and such long-term survival information are few and difficult to gather.

PATIENTS AND METHODS: We recruited 253 breast cancer patients who undertook operation with no prior chemotherapy. Ten-year survival outcomes were evaluated by clinicopathological factors.

RESULTS: Significant univariate prognostic factors were: T factor, N factor, preoperative values of tumor markers, and biological factors. T-factor, CEA, hormone receptor, and Ki-67 were the final independent prognostic factors of recurrence-free survival through multivariate analysis. The Luminal A group except for the Ki-67-positive cases showed the best survival outcomes, while the HER2-positive or triple-negative (TN) groups showed worse prognosis than the Luminal A group, and Ki-67 was shown to be an excellent prognostic factor in each stage (p<0.01).

CONCLUSION: Ki-67 has a great potential as a prognostic biomarker while prognostic information of this sort could be beneficial for development of novel therapeutic strategies.

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