In and out of the bone: can the osteocyte escape skeletal jail and yet regulate mineralization?

Junichiro J Kazama, Masafumi Fukagawa
Kidney International 2014, 85 (1): 11-2
An increase in the levels of fibroblast growth factor 23 (FGF23) develops in the early phase of chronic kidney disease (CKD). However, the initial trigger of CKD-mineral and bone disorder (CKD-MBD) is a matter of debate. Fang and associates provide evidence, in a mouse model of early CKD, that osteocytes and osteocyte-like cells play an important role at the earliest stage of CKD-MBD. The osteocytes may become a target of intervention in CKD-MBD.

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