Carbamazepine treatment of generalized tonic-clonic seizures in idiopathic generalized epilepsy

Katharine Kenyon, Scott Mintzer, Maromi Nei
Seizure: the Journal of the British Epilepsy Association 2014, 23 (3): 234-6

PURPOSE: Evaluate the efficacy of carbamazepine in the treatment of idiopathic generalized epilepsy (IGE).

METHOD: The response of five patients with IGE, who experienced primarily generalized tonic-clonic seizures which were refractory to multiple antiepileptic drugs, is reported.

RESULTS: Carbamazepine controlled multiple seizure types and did not induce or increase the frequency of myoclonic or absence seizures in these patients. Many family members also responded favorably to carbamazepine.

CONCLUSION: Carbamazepine can be used with caution as an alternative treatment option for refractory IGE, especially in cases in which the main seizure type is generalized tonic-clonic.

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