Whipple's disease confined to the central nervous system

M Adams, P A Rhyner, J Day, S DeArmond, E A Smuckler
Annals of Neurology 1987, 21 (1): 104-8
Progressive hypersomnia, memory disturbance, and vertical ophthalmoplegia developed in a 63-year-old woman. The diagnosis of Whipple's disease of the central nervous system was suggested by her presentation and results of studies using magnetic resonance imaging. Despite a one-month course of antibiotics, active Whipple's disease, localized to the central nervous system, was found at autopsy.

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