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Severe pertussis and hyperleukocytosis: is it time to change for exchange?
Transfusion 2014 June
BACKGROUND: Pertussis is an important cause of infant death worldwide and continues to be a public health concern even in countries with high vaccination coverage. Severe (critical) pertussis with hyperleukocytosis is a severe form of the disease with up to 80% mortality rate. Attempts have been reported to reduce the white blood cell burden by exchange transfusion (ET) with conflicting conclusions.
CASE REPORT: We report a case of critical pertussis in a neonate who was treated with ET, in view of a comprehensive literature review.
RESULTS: The patient was discharged without any sequelae.
CONCLUSION: ET should be considered in all infants suffering from critical pertussis and hyperleukocytosis, even in secondary care community hospitals.
CASE REPORT: We report a case of critical pertussis in a neonate who was treated with ET, in view of a comprehensive literature review.
RESULTS: The patient was discharged without any sequelae.
CONCLUSION: ET should be considered in all infants suffering from critical pertussis and hyperleukocytosis, even in secondary care community hospitals.
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