MicroRNA-490-5p inhibits proliferation of bladder cancer by targeting c-Fos

Shiqi Li, Xianglai Xu, Xin Xu, Zhenghui Hu, Jian Wu, Yi Zhu, Hong Chen, Yeqing Mao, Yiwei Lin, Jindan Luo, Xiangyi Zheng, Liping Xie
Biochemical and Biophysical Research Communications 2013 November 29, 441 (4): 976-81
MicroRNAs (miRNAs) are non-protein-coding sequences that play a crucial role in tumorigenesis by negatively regulating gene expression. Here, we found that miR-490-5p is down-regulated in human bladder cancer tissue and cell lines compared to normal adjacent tissue and a non-malignant cell line. To better characterize the function of miR-490-5p in bladder cancer, we over-expressed miR-490-5p in bladder cancer cell lines with chemically synthesized mimics. Enforced expression of miR-490-5p in bladder cancer cells significantly inhibited the cell proliferation via G1-phase arrest. Further studies found the decreased c-Fos expression at both mRNA and protein levels and Luciferase reporter assays demonstrated that c-Fos is a direct target of miR-490-5p in bladder cancer. These findings indicate miR-490-5p to be a novel tumor suppressor of bladder cancer cell proliferation through targeting c-Fos.

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