JOURNAL ARTICLE

A simple and pH-independent and ultrasensitive fluorescent probe for the rapid detection of Hg2+

Ai-Li Luo, Yi-Jun Gong, Yuan Yuan, Jing Zhang, Cui-Cui Zhang, Xiao-Bing Zhang, Weihong Tan
Talanta 2013 December 15, 117: 326-32
24209348
Development of fluorescent probes for Hg(2+) has become a hot topic in modern chemical research due to its high toxicity. In this paper, we for the first time report the synthesis and application of a thioether spirocyclic rhodamine B derivative (TR) as an efficient fluorescent probe for Hg(2+). TR was synthesized using a simple procedure under mild condition. By employing a thioether spirocycle instead of classic spirolactam as recognition unit, our proposed probe TR is acidity-insensitive, and exhibits a pH-independent and ultrasensitive response to Hg(2+). The probe works well within a wide pH range from 3.5 to 11.5, and exhibits a 350-fold fluorescence enhancement upon 0.5 equiv of Hg(2+) triggered, with a detection limit of 2.5 nM estimated for Hg(2+). In virtue of the strong thiophilic characteristic of Hg(2+), the response of the probe to Hg(2+) is instantaneous and highly selective, which make it favorable for cellular Hg(2+) imaging applications. It has been preliminarily used for highly sensitive monitoring of Hg(2+) level in living cells with satisfying resolution, demonstrating its value of the practical applications in biological systems.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
24209348
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"