Dysfunction of Corticomotoneurons in Guillain-Barré Syndrome (GBS)?

Guillain-Barré syndrome (GBS) is characterized by acute and symmetric flaccid paraparesis and areflexia. Involvement of the central nervous system has been infrequently reported. In the current issue of Clinical Medicine: Case reports, an unusual case of GBS with asymmetric muscle weakness was reported. Corticomotoneuronal dysfunction was invoked as a possible cause for this neurological finding. Reversible blockade of voltage gated Na(+) channels resulting in conduction failure may be a possible pathophysiological mechanism.