C3 glomerulopathy: consensus report

Matthew C Pickering, Vivette D D'Agati, Carla M Nester, Richard J Smith, Mark Haas, Gerald B Appel, Charles E Alpers, Ingeborg M Bajema, Camille Bedrosian, Michael Braun, Mittie Doyle, Fadi Fakhouri, Fernando C Fervenza, Agnes B Fogo, Véronique Frémeaux-Bacchi, Daniel P Gale, Elena Goicoechea de Jorge, Gene Griffin, Claire L Harris, V Michael Holers, Sally Johnson, Peter J Lavin, Nicholas Medjeral-Thomas, B Paul Morgan, Cynthia C Nast, Laure-Hélène Noel, D Keith Peters, Santiago Rodríguez de Córdoba, Aude Servais, Sanjeev Sethi, Wen-Chao Song, Paul Tamburini, Joshua M Thurman, Michael Zavros, H Terence Cook
Kidney International 2013, 84 (6): 1079-89
C3 glomerulopathy is a recently introduced pathological entity whose original definition was glomerular pathology characterized by C3 accumulation with absent or scanty immunoglobulin deposition. In August 2012, an invited group of experts (comprising the authors of this document) in renal pathology, nephrology, complement biology, and complement therapeutics met to discuss C3 glomerulopathy in the first C3 Glomerulopathy Meeting. The objectives were to reach a consensus on: the definition of C3 glomerulopathy, appropriate complement investigations that should be performed in these patients, and how complement therapeutics should be explored in the condition. This meeting report represents the current consensus view of the group.

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