JOURNAL ARTICLE

Intracerebral delivery of a third generation EGFRvIII-specific chimeric antigen receptor is efficacious against human glioma

Bryan D Choi, Carter M Suryadevara, Patrick C Gedeon, James E Herndon, Luis Sanchez-Perez, Darell D Bigner, John H Sampson
Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia 2014, 21 (1): 189-90
24054399
Chimeric antigen receptors (CAR)-transduced T cells hold great promise in the treatment of malignant disease. Here, we demonstrate that intracerebral injection with a human, epidermal growth factor receptor variant III (EGFRvIII)-specific, third generation CAR successfully treats glioma in mice. Importantly, these results endorse clinical translation of this CAR in patients with EGFRvIII-expressing brain tumors.

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