JOURNAL ARTICLE
RANDOMIZED CONTROLLED TRIAL

Sublingual misoprostol versus intravenous oxytocin in prevention of post-partum hemorrhage

Renu Tewatia, Shikha Rani, Usha Srivastav, Bela Makhija
Archives of Gynecology and Obstetrics 2014, 289 (4): 739-42
24045979

BACKGROUND: Post-partum hemorrhage (PPH) is the most common direct cause of maternal mortality and timely intervention can save many lives.

OBJECTIVE: To compare the effectiveness of sublingual misoprostol to intravenous oxytocin in preventing post-partum hemorrhage in low risk vaginal birth.

METHODS: One hundred patients with no risk factor for PPH were randomly allocated to receive 600 μg misoprostol administered sublingually or 10 IU of intravenous oxytocin immediately after the delivery of baby. Main outcome measures were post-partum blood loss, drop in hemoglobin in 24 h, duration of third stage of labor, and drug-related adverse effects.

RESULTS: Mean age, parity and gestational age were similar in both groups. Mean blood loss was significantly lower in oxytocin group (114.28 ± 26.75 versus 149.50 ± 30.78 ml; p = 0.00). Drop in hemoglobin was 0.31 ± 0.16 versus 0.49 ± 0.21 g% (p = 0.01) in oxytocin and misoprostol group, respectively. Duration of third stage labor was shorter in oxytocin group (median 5 min, IQR: 4.5-5.5 versus 5.5 min, IQR: 5-6 min, p < 0.01). Although fever and shivering were common adverse effects with misoprostol but were not clinically significant.

CONCLUSION: Intravenous oxytocin is more efficacious than sublingual misoprostol in preventing PPH in institutional deliveries.

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