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Mechanisms of targeted therapy resistance take a de-TOR.

Leanna R Gentry, Timothy D Martin, Channing J Der
Cancer Cell 2013 September 10
The effectiveness of cancer therapeutics targeting signal transduction pathways is comprised of a diversity of mechanisms that drive de novo or acquired resistance. Two recent studies identify mTOR activation as a point of convergence of mechanisms that cause resistance to inhibitors of the Raf-MEK-ERK and PI3K signaling.

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