Differential expression of miR-195 in esophageal squamous cell carcinoma and miR-195 expression inhibits tumor cell proliferation and invasion by targeting of Cdc42

Min-gen Fu, Shuo Li, Ting-ting Yu, Li-juan Qian, Ri-sheng Cao, Hong Zhu, Bin Xiao, Chun-hua Jiao, Na-na Tang, Jing-jing Ma, Jie Hua, Wei-feng Zhang, Hong-jie Zhang, Rui-hua Shi
FEBS Letters 2013 November 1, 587 (21): 3471-9
MicroRNAs (miRNA) have played an important role in carcinogenesis. In this study, Agilent miRNA microarray was used to identify differentially expressed miRNAs in esophageal squamous cell carcinoma (ESCC) tissues and miR-195 was downregulated in ESCC compared with normal esophageal tissues. Moreover, Cdc42 was confirmed as target gene of miR-195. Ectopic expression of miR-195 in ESCC cells significantly downregulated Cdc42 by directly binding its 3' untranslated regions, and induced G1 cell cycle arrest, leading to a significant decrease in cell growth, migration, and invasion in vitro. Therefore, our findings demonstrated that miR-195 may act as a tumor suppressor in ESCC by targeting Cdc42.

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