[Secondary osteoporosis or secondary contributors to bone loss in fracture. Metabolic bone disease and fracture induced by drugs]

Hisanori Suzuki
Clinical Calcium 2013, 23 (9): 1307-12
Many medications can increase fracture risk. Osteoporosis is classified as either primary or secondary. Drug-induced osteoporosis is a type of secondary osteoporosis. Glucocorticoids are the most common cause of drug-induced osteoporosis. But other drugs can increase fracture risk, such as thyroxine overdose, gonadotropin-releasing hormone (GnRH) agonists, aromatase inhibitors, thiazolidines, proton pump inhibitors, loop diuretics, anticoagulant drugs, selective serotonin reuptake inhibitors (SSRI) , tricyclic antidepressants, anticonvulsant, and so on. This review will discuss clinical trials and the mechanisms underlying drug-induced fracture.

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