A rhodamine-based fluorescent probe for detecting Hg(2+) in a fully aqueous environment

Xiaoli Chen, Xiangming Meng, Shuxing Wang, Yulei Cai, Yifan Wu, Yan Feng, Manzhou Zhu, Qingxiang Guo
Dalton Transactions: An International Journal of Inorganic Chemistry 2013 October 1, 42 (41): 14819-25
A water-soluble fluorescent probe for Hg(2+) based on a rhodamine B derivative was designed and synthesized. The new probe showed reversible colorimetric and fluorescent response to Hg(2+) in a fully aqueous solution. The probe exhibited real-time detection of Hg(2+) with high selectivity in media containing less than 1% organic cosolvent. Furthermore, bioimaging studies indicated that the new probe was cell permeable and suitable for the real-time imaging of Hg(2+) in living cells by confocal microscopy.

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