JOURNAL ARTICLE

MiR-101 inhibits melanoma cell invasion and proliferation by targeting MITF and EZH2

Chonglin Luo, Patrick R Merz, Yiwei Chen, Elke Dickes, Armin Pscherer, Dirk Schadendorf, Stefan B Eichmüller
Cancer Letters 2013 December 1, 341 (2): 240-7
23962556
The microRNA miR-101 has been reported to be a tumor suppressor. Here we show that low expression of miR-101 is associated with poor survival in stage IV melanoma patients. We identified microphthalmia-associated transcription factor (MITF) as a direct target of miR-101. In melanoma cells, overexpression of miR-101 downregulated protein levels of MITF and a previously reported target protein, enhancer of zeste homolog 2 (EZH2). Functional assays showed that miR-101 suppressed invasion and proliferation - an outcome that could be phenocopied by siRNA knockdown of MITF and EZH2. Our data suggest that miR-101 might have a beneficial role in melanoma.

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