Bilateral areolar leiomyomas in a patient undergoing BRAF inhibition therapy for melanoma

Michael Clarke, Bernhard Ortel, Bruce Brockstein, Theera Rojanapremsuk, Thomas Victor, Antoinette Thomas, Thomas Cibull
Journal of Cutaneous Pathology 2013, 40 (10): 884-6
BRAF inhibition therapy, used to treat melanomas with BRAF mutations, is associated with both neoplastic and non-neoplastic cutaneous side effects including squamous cell carcinomas, warty dyskeratomas, verrucous keratoses, photosensitivity and widespread eruptions that present histopathologically as acantholytic dyskeratosis. We report a case of a patient undergoing BRAF inhibition therapy for disseminated melanoma with a V600E mutation who developed bilateral areolar leiomyomas, one of which was biopsied and the other of which resolved after discontinuation of vemurafenib therapy. To our knowledge, this is the first reported case of a mesenchymal neoplasm developing in association with BRAF inhibition therapy.

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