Bioassay-guided isolation of neo-clerodane diterpenoids from Scutellaria barbata

Yuan-Yuan Li, Xu-Li Tang, Tao Jiang, Pei-Fen Li, Ping-Lin Li, Guo-Qiang Li
Journal of Asian Natural Products Research 2013, 15 (9): 941-9
Bioassay-guided isolation of the aerial part of Scutellaria barbata yielded three new neo-clerodane diterpenoids scutebatas P-R (1-3), together with two known ones: scutebata E (4) and scutebarbatine B (5). The chemical structures of the isolated compounds were elucidated by spectroscopic methods (NMR and MS) and by comparison with the spectroscopic data reported in the literature. All compounds except 3 showed weak cytotoxicity with IC50 values ranging from 35.11 to 42.73 μM against K562 cell lines, and compounds 1, 2, and 5 also displayed weak activities against HL60 cell lines.


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