Rhodamine cyclic hydrazide as a fluorescent probe for the detection of hydroxyl radicals

Minjeong Kim, Sung-Kyun Ko, Hyemi Kim, Injae Shin, Jinsung Tae
Chemical Communications: Chem Comm 2013 September 18, 49 (72): 7959-61
A new rhodamine fluorescent probe for monitoring ˙OH has been developed based on the oxidative C-H abstraction reaction of rhodamine cyclic hydrazide. The probe exhibits excellent selectivity for ˙OH with virtually no interference by other ROS/RNS species. Fluorescent imaging of A549 and RAW264.7 cells is also successfully demonstrated to detect intracellular ˙OH in live cells.

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