JOURNAL ARTICLE

Fear-enhancing effects of septal oxytocin receptors

Yomayra F Guzmán, Natalie C Tronson, Vladimir Jovasevic, Keisuke Sato, Anita L Guedea, Hiroaki Mizukami, Katsuhiko Nishimori, Jelena Radulovic
Nature Neuroscience 2013, 16 (9): 1185-7
23872596
The nonapeptide oxytocin is considered beneficial to mental health due to its anxiolytic, prosocial and antistress effects, but evidence for anxiogenic actions of oxytocin in humans has recently emerged. Using region-specific manipulations of the mouse oxytocin receptor (Oxtr) gene (Oxtr), we identified the lateral septum as the brain region mediating fear-enhancing effects of Oxtr. These effects emerge after social defeat and require Oxtr specifically coupled to the extracellular signal-regulated protein kinase pathway.

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