Pancytopenia related to dental adhesive in a young patient

Farhard Khimani, Ryan Livengood, Olukemi Esan, Jeffrey A Vos, Vivek Abhyankar, Ludwig Gutmann, William Tse
American Journal of Stem Cells 2013, 2 (2): 132-6
Copper deficiency resulting in hypocupremia is a rare cause of pancytopenia associated with a neurological syndrome. Hypocupremia may also occur as a consequence of excessive oral zinc consumption as described by Brewer et al and several other groups. Dental fixatives have been described as a potential source of hyperzincemia in patients. Despite the recently modified dental fixatives with safer zinc content, zinc poisoning results in hypocupremia secondary to inappropriate use of them can still happen and more likely be misdiagnosed. We describe a case of a patient with pancytopenia who was diagnosed with severe aplastic anemia and hypocellular myelodysplastic syndrome and was referred to us for consideration of bone marrow transplantation.

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