We have located links that may give you full text access.
Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't
Corticosteroid therapy in IgA nephropathy with minimal change-like lesions: a single-centre cohort study.
Nephrology, Dialysis, Transplantation 2013 September
BACKGROUND: There is a lack of high-quality evidence that advocates the use of corticosteroids for IgA nephropathy (IgAN) with minimal change-like lesions (also called IgAN with minimal change disease, MCD-IgAN).
METHODS: Twenty-seven biopsy-proven adult MCD-IgAN patients were enrolled. Daily single dose of 1 mg/kg (maximum 60 mg/day) prednisone was given until complete remission (CR), followed by gradually decreasing dosage. The clinical data were collected from baseline up to 12 weeks of treatment (Certification No. 2011NLY-006, Clinical trials gov ID. NCT01451710).
RESULTS: The patient cohort consisted of 15 males and 12 females. The mean age of the patients was 29.2 ± 10.8 years (range 18-60 years) at the time when they were subject to renal biopsy. All patients had hypoalbuminaemia (23.7 ± 4.13 g/L) and heavy proteinuria (>3.5 g/24 h). Cumulative CR (proteinuria < 0.4 g/24 h) rates were 3.70, 48.1, 92.6 and 100% after 1, 2, 4 and 8 weeks of treatment, respectively. Two cases relapsed after CR, one at 6 weeks of treatment, likely due to failure to follow the corticosteroid withdrawal schedule, and the other one at 8 weeks of treatment accompanied with an upper respiratory infection. Infection, alanine aminotransferase elevation (>2-folds), fasting blood glucose (FBG) elevation (>6.2 mmol/L) and hypopotassaemia (<3.5 mmol/L) occurred in 2, 5, 2 and 5 cases, respectively, but were eliminated after treatment.
CONCLUSION: Corticosteroid therapy is likely effective and safe for MCD-IgAN patients.
METHODS: Twenty-seven biopsy-proven adult MCD-IgAN patients were enrolled. Daily single dose of 1 mg/kg (maximum 60 mg/day) prednisone was given until complete remission (CR), followed by gradually decreasing dosage. The clinical data were collected from baseline up to 12 weeks of treatment (Certification No. 2011NLY-006, Clinical trials gov ID. NCT01451710).
RESULTS: The patient cohort consisted of 15 males and 12 females. The mean age of the patients was 29.2 ± 10.8 years (range 18-60 years) at the time when they were subject to renal biopsy. All patients had hypoalbuminaemia (23.7 ± 4.13 g/L) and heavy proteinuria (>3.5 g/24 h). Cumulative CR (proteinuria < 0.4 g/24 h) rates were 3.70, 48.1, 92.6 and 100% after 1, 2, 4 and 8 weeks of treatment, respectively. Two cases relapsed after CR, one at 6 weeks of treatment, likely due to failure to follow the corticosteroid withdrawal schedule, and the other one at 8 weeks of treatment accompanied with an upper respiratory infection. Infection, alanine aminotransferase elevation (>2-folds), fasting blood glucose (FBG) elevation (>6.2 mmol/L) and hypopotassaemia (<3.5 mmol/L) occurred in 2, 5, 2 and 5 cases, respectively, but were eliminated after treatment.
CONCLUSION: Corticosteroid therapy is likely effective and safe for MCD-IgAN patients.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app