Erythrocytosis in children and adolescents-classification, characterization, and consensus recommendations for the diagnostic approach

Holger Cario, Mary Frances McMullin, Celeste Bento, Dagmar Pospisilova, Melanie J Percy, Kais Hussein, Jiri Schwarz, Maria Aström, Sylvie Hermouet
Pediatric Blood & Cancer 2013, 60 (11): 1734-8
During recent years, the increasing knowledge of genetic and physiological changes in polycythemia vera (PV) and of different types of congenital erythrocytosis has led to fundamental changes in recommendations for the diagnostic approach to patients with erythrocytosis. Although widely accepted for adult patients this approach may not be appropriate with regard to children and adolescents affected by erythrocytosis. The "congenital erythrocytosis" working group established within the framework of the MPN&MPNr-EuroNet (COST action BM0902) addressed this question in a consensus finding process and developed a specific algorithm for the diagnosis of erythrocytosis in childhood and adolescence which is presented here.

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