Mineral constituents and toxicological profile of Jateorhiza macrantha (Menispermaceae) aqueous extract

Bibi-Farouck Aboubakar Oumarou, Linda Martiale Tchuemdem, Paul Désiré Dzeufiet Djomeni, Danielle Claude Bilanda, Esther Ngo Lemba Tom, Martin Thierry Bella Ndzana, Dimo Théophile
Journal of Ethnopharmacology 2013 August 26, 149 (1): 117-22

ETHNOPHARMACOLOGICAL RELEVANCE: Jateorhiza macrantha is a medicinal plant used in popular medicine to treat several diseases, including cardiovascular disorders. To date, there is no documented report available on the toxicological profile of this medicinal plant.

THE AIM OF THE STUDY: The present study was carried out to investigate the mineral content and the safety of the oral administration of the leaf aqueous extract of Jateorhiza macrantha in mice.

MATERIALS AND METHODS: The presence of Ca, Mg, K, Na, Cu, Mn, Fe and Zn in the extract was analyzed using Atomic Absorption Spectrophotometer. In the acute toxicity study, Male and female Balb-C mice were administered single doses of 2.5 and 5 g/kg of body weight by gavage, and were monitored for 7 days. In the subacute toxicity study, the extract was administered by gavage at doses of 150, 300 and 600 mg/kg body weight daily for 6 weeks to mice (8 mice/dose/sex). After this period of treatment, 5 mice per sex and per group were sacrificed. The rest of animals per group were observed without any treatment for 2 weeks. After the treatments, some biochemical and hematological parameters were analyzed.

RESULTS: Our findings indicate the presence of all mineral elements tested. Acute study indicates no signs of toxicity at the doses used. The LD50 value is >5.00 g/kg body weight, since there was no death registered at that dose. In subacute study, hematological and biochemical parameters showed a significant decrease in platelet and significant increases in ALT and AST in both sexes and creatinin levels only in male suggesting that some compounds of the plant extract were responsible of disturbances of hematopoiesis, liver and kidney functions.

CONCLUSIONS: Our results show that Jateorhiza macrantha acute toxicity towards animals is very low. However, in subacute administration, this extract induces slight injuries on hematopoiesis, liver and kidney functions, suggesting its use with caution.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"