Peroral endoscopic myotomy for the treatment of achalasia: an international prospective multicenter study

Daniel Von Renteln, Karl-Hermann Fuchs, Paul Fockens, Peter Bauerfeind, Melina C Vassiliou, Yuki B Werner, Gerald Fried, Wolfram Breithaupt, Henriette Heinrich, Albert J Bredenoord, Jan F Kersten, Tessa Verlaan, Michael Trevisonno, Thomas Rösch
Gastroenterology 2013, 145 (2): 309-11.e1-3
Pilot studies have indicated that peroral endoscopic myotomy (POEM) might be a safe and effective treatment for achalasia. We performed a prospective, international, multicenter study to determine the outcomes of 70 patients who underwent POEM at 5 centers in Europe and North America. Three months after POEM, 97% of patients were in symptom remission (95% confidence interval, 89%-99%); symptom scores were reduced from 7 to 1 (P < .001) and lower esophageal sphincter pressures were reduced from 28 to 9 mm Hg (P < .001). The percentage of patients in symptom remission at 6 and 12 months was 89% and 82%, respectively. POEM was found to be an effective treatment for achalasia after a mean follow-up period of 10 months.

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