Long-term neurodevelopmental and cardiovascular outcome after intrauterine transfusions for fetal anaemia: a review

Irene T M Lindenburg, Jeanine M van Klink, Vivianne E H J Smits-Wintjens, Inge L van Kamp, Dick Oepkes, Enrico Lopriore
Prenatal Diagnosis 2013, 33 (9): 815-22
Perinatal survival rates after intrauterine transfusions (IUT) for red cell alloimmunisation now exceed 90%, which demonstrates the safety and efficacy of one of the most successful procedures in fetal therapy. However, improved perinatal survival could lead to an increased number of children with long-term disabilities. The importance of long-term follow-up studies in fetal therapy lies in both the necessity of evaluation of antenatal management as well as in evidence-based preconceptional and prenatal counselling. This review describes the possible long-term cardiovascular and neurodevelopmental sequelae after IUT treatment for different indications including red cell alloimmunisation, parvovirus B19 infection, fetomaternal haemorrhage and twin anaemia-polycythaemia sequence.

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