Significant response to oral Etoposide in the treatment of an unresectable cardiac sarcoma

Chelsea L Collins, Peter J Bartz, David R Lal, Annette D Segura, Ronald K Woods, Richard L Tower
Journal of Pediatric Hematology/oncology 2014, 36 (4): e237-40
Primary cardiac sarcomas are rare and carry a poor prognosis. The standard of care is complete resection. Outcomes for patients without complete resection are dismal, and the benefit of adjuvant therapy is uncertain. A 9-year-old girl presented with a large right-sided cardiac mass. After biopsy, the tumor was classified as an undifferentiated sarcoma. Resection was not feasible due to apparent invasion of the right ventricle and atrioventricular groove. Treatment with oral etoposide resulted in a 97% reduction in tumor volume and allowed for complete resection of residual tumor. She is alive with no evidence of disease 25 months from diagnosis.

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