We have located links that may give you full text access.
Stimulatory effect of gonadal hormones on fetal rat hippocampal neural proliferation requires neurotrophin receptor activation in vitro.
Neuroscience Letters 2013 June 25
To determine the effects of gonadal hormones on proliferation of the hippocampal neural cells, which are of importance in learning and memory function. 17β-Estradiol or testosterone was added to the culture at various concentrations. Their proliferation and protective effects on the neural cell were determined with BrdU, flow cytometry and MTT assay. Effects of the gonadal hormones on brain-derived neurotrophic factor (BDNF) expression were determined using ELISA and RT-PCR respectively. 17β-Estradiol and testosterone at 20nM or higher concentrations significantly increased the neural cell proliferation and viability, and induced increasing in the S phase arrest which is essential for cell proliferation. Both estradiol and testosterone significantly increased the neural cell expression of cellular mature BDNF and BDNF mRNA. Effect of testosterone on hippocampal neural proliferation was blocked by Trk neurotrophin receptor inhibitor. 17β-Estradiol and testosterone promoted hippocampal neural proliferation and improved cell viability in vitro. The effect of testosterone on hippocampal neural cell proliferation required neurotrophin receptor activation.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app