OPEN IN READ APP
JOURNAL ARTICLE

Effects of watermelon supplementation on arterial stiffness and wave reflection amplitude in postmenopausal women

Arturo Figueroa, Alexei Wong, Shirin Hooshmand, Marcos Angel Sanchez-Gonzalez
Menopause: the Journal of the North American Menopause Society 2013, 20 (5): 573-7
23615650

OBJECTIVE: Postmenopausal women have increased arterial stiffness (brachial-ankle pulse wave velocity [baPWV]) and wave reflection. L-Citrulline supplementation reduces baPWV but not brachial blood pressure. Peripheral vasodilators decrease wave reflection amplitude or second systolic peak (SBP2) in radial artery and aorta, which are related to aortic systolic blood pressure (SBP). We examined the effects of L-citrulline-rich watermelon supplementation on baPWV, wave reflection characteristics, and aortic SBP in postmenopausal women.

METHODS: In a randomized cross-over study, 12 postmenopausal women (mean [SE] age, 57 [1] y; mean [SE] body mass index, 38.1 [2.1] kg/m; mean [SE] SBP, 153 [4] mm Hg) were assigned to watermelon supplementation (L-citrulline/L-arginine 6 g/d) or placebo supplementation for 6 weeks. Before and after each intervention, baPWV, aortic SBP, aortic diastolic blood pressure, aortic SBP2, radial SBP2, and aortic and radial augmentation indices were measured using applanation tonometry.

RESULTS: baPWV (-1.2 [0.3] m/s, P < 0.001), aortic SBP (-10 [3] mm Hg, P < 0.01), and aortic diastolic blood pressure (-7 [1] mm Hg, P < 0.001) decreased after watermelon supplementation compared with placebo. Although radial and aortic augmentation indices were unaffected, radial and aortic SBP2 decreased (-10 [3] mm Hg, P < 0.01) after watermelon supplementation compared with placebo. The reduction in aortic SBP was correlated with reductions in radial SBP2 (r = 0.99, P < 0.001) and aortic SBP2 (r = 0.98, P < 0.001). The decreases in baPWV correlated with reductions in radial SBP2 (r = 0.57, P < 0.01) and aortic SBP2 (r = 0.64, P < 0.01).

CONCLUSIONS: Watermelon supplementation reduces arterial stiffness and aortic SBP by reducing pressure wave reflection amplitude in obese postmenopausal women with hypertension.

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Available on the App Store

Available on the Play Store
Remove bar
Read by QxMD icon Read
23615650
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"