JOURNAL ARTICLE

Cartilage degradation in temporomandibular joint induced by unilateral anterior crossbite prosthesis

Y L Wang, J Zhang, M Zhang, L Lu, X Wang, M Guo, X Zhang, M Q Wang
Oral Diseases 2014, 20 (3): 301-6
23614573

OBJECTIVE: To investigate the pathological effects on temporomandibular joint cartilage of an experimentally created unilateral anterior crossbite prosthesis.

METHODS: Six-week-old female Sprague-Dawley rats were divided into experimental and control groups and further divided into three subgroups for three time points (n = 9). In experimental groups, the unilateral anterior crossbite was created by bonding two metal tubes on left maxillary and mandibular incisors. 2, 4, or 8 weeks after operation, the histomorphological changes and the expression changes of PCNA, COL II, aggrecan, MMP-3, MMP-9, MMP-13, and TIMP-1 in condylar cartilage were investigated by hematoxylin-eosin and toluidine blue staining, real-time PCR, and immunohistochemistry.

RESULTS: In experimental groups, decreasing in chondrocytes, cell-free areas, reduction in the thickness of hypertrophic layer, and loss of extracellular matrix were noticed. The expression level of PCNA was decreased at week 2 and week 4. The mRNA expression of COL II was decreased at 4 week and that of aggrecan was increased at 2 week but decreased at 4 and 8 week. The expression of MMP-9, MMP-13, and TIMP-1 was increased at 2-week and decreased at 4- and 8-week, while that of MMP-3 was increased at 4- and 8-week.

CONCLUSIONS: The present unilateral anterior crossbite prosthesis led to degradation of mandibular condylar cartilage.

Full Text Links

Find Full Text Links for this Article

Discussion

You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read
23614573
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"