Cartilage degradation in temporomandibular joint induced by unilateral anterior crossbite prosthesis

Y L Wang, J Zhang, M Zhang, L Lu, X Wang, M Guo, X Zhang, M Q Wang
Oral Diseases 2014, 20 (3): 301-6

OBJECTIVE: To investigate the pathological effects on temporomandibular joint cartilage of an experimentally created unilateral anterior crossbite prosthesis.

METHODS: Six-week-old female Sprague-Dawley rats were divided into experimental and control groups and further divided into three subgroups for three time points (n = 9). In experimental groups, the unilateral anterior crossbite was created by bonding two metal tubes on left maxillary and mandibular incisors. 2, 4, or 8 weeks after operation, the histomorphological changes and the expression changes of PCNA, COL II, aggrecan, MMP-3, MMP-9, MMP-13, and TIMP-1 in condylar cartilage were investigated by hematoxylin-eosin and toluidine blue staining, real-time PCR, and immunohistochemistry.

RESULTS: In experimental groups, decreasing in chondrocytes, cell-free areas, reduction in the thickness of hypertrophic layer, and loss of extracellular matrix were noticed. The expression level of PCNA was decreased at week 2 and week 4. The mRNA expression of COL II was decreased at 4 week and that of aggrecan was increased at 2 week but decreased at 4 and 8 week. The expression of MMP-9, MMP-13, and TIMP-1 was increased at 2-week and decreased at 4- and 8-week, while that of MMP-3 was increased at 4- and 8-week.

CONCLUSIONS: The present unilateral anterior crossbite prosthesis led to degradation of mandibular condylar cartilage.

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