18F-FLT PET/CT imaging is not competent for the pretreatment evaluation of metastatic gastric cancer: a comparison with 18F-FDG PET/CT imaging

Min Zhou, Chenchen Wang, Silong Hu, Yongping Zhang, Zhifeng Yao, Jin Li, Weijian Guo, Yingjian Zhang
Nuclear Medicine Communications 2013, 34 (7): 694-700

OBJECTIVE: The aim of this study was to evaluate the utility of 3'-deoxy-3'-F-fluorothymidine (F-FLT) PET/computed tomography (CT) imaging in the pretreatment evaluation of metastatic gastric cancer in comparison with F-fluorodeoxyglucose (F-FDG) PET/CT imaging.

METHODS: A total of 39 metastatic gastric cancer patients were enrolled in the study. Attenuation-corrected whole-body F-FLT and F-FDG PET/CT (low-dose CT) imaging was performed on two consecutive days before chemotherapy.

RESULTS: Accumulation of focal activity was visible in primary tumors on F-FLT PET/CT in 36/39 patients and on F-FDG PET/CT in 37/39 patients, with sensitivities of 92.3 and 94.9%, respectively. Further, three of the 36 FLT-avid primary tumors were almost undetected because they were covered by a high background hepatic uptake. Because of the high physiological uptake of F-FLT in the liver [median maximum standardized uptake value (SUVmax) 5.5, range 4.5-8.3] and the bone marrow (median SUVmax 14.8, range 10.8-22.0), the sensitivity of F-FLT PET/CT versus F-FDG PET/CT for detecting liver metastases and bone metastases was 30.0% (6/20) versus 100% (20/20) and 1/5 (20.0%) versus 5/5 (100%), respectively (P<0.05). Metabolically positive findings of lymph node, peritoneal, and ovarian metastases were similar between the two modalities: 96.8% (30/31) versus 93.5% (29/31), 89.5% (17/19) versus 94.7% (18/19), and 90.9% (10/11) versus 90.9% (10/11) of patients for F-FLT versus F-FDG, respectively (P>0.05).

CONCLUSION: F-FLT PET/CT imaging is not recommended for pretreatment assessment of metastatic gastric cancer as it is not competent enough to evaluate liver and bone metastases; moreover, the high background hepatic uptake may cover the gastric primary tumors located adjacent to the liver.

Full Text Links

Find Full Text Links for this Article


You are not logged in. Sign Up or Log In to join the discussion.

Related Papers

Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"