Development of pyloric stenosis after a 4-day course of oral erythromycin

Luis E Lozada, Matthew J Royall, Cade M Nylund, Matthew D Eberly
Pediatric Emergency Care 2013, 29 (4): 498-9
Early exposure to oral erythromycin in young infants, particularly in the first 2 weeks of life, has previously been associated with the development of hypertrophic pyloric stenosis. We report a case of an infant who received an abbreviated 4-day course of oral erythromycin for suspected Chlamydia conjunctivitis at 5 days of life then underwent pyloromyotomy for pyloric stenosis less than 2 weeks later. Health care providers should use erythromycin judiciously in neonates because only a few days of exposure to this medication may lead to the development of a surgical condition of gastric outlet obstruction.

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