Continuous processing and the applications of online tools in pharmaceutical product manufacture: developments and examples

Shing Ming Ooi, Srimanta Sarkar, Griet van Varenbergh, Kris Schoeters, Paul Wan Sia Heng
Therapeutic Delivery 2013, 4 (4): 463-70
Continuous processing and production in pharmaceutical manufacturing has received increased attention in recent years mainly due to the industries' pressing needs for more efficient, cost-effective processes and production, as well as regulatory facilitation. To achieve optimum product quality, the traditional trial-and-error method for the optimization of different process and formulation parameters is expensive and time consuming. Real-time evaluation and the control of product quality using an online process analyzer in continuous processing can provide high-quality production with very high-throughput at low unit cost. This review focuses on continuous processing and the application of different real-time monitoring tools used in the pharmaceutical industry for continuous processing from powder to tablets.

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