JOURNAL ARTICLE

Role of TRPM2 cation channels in dorsal root ganglion of rats after experimental spinal cord injury

Mustafa Naziroğlu, Abdülhadi Cihangir Uğuz, Özgür Ismailoğlu, Bilal Çiğ, Cemil Özgül, Muhammed Borcak
Muscle & Nerve 2013, 48 (6): 945-50
23512594

INTRODUCTION: We sought to determine the contribution of oxidative stress-dependent activation of TRPM2 and L-type voltage-gated Ca(2+) channels (VGCC) in dorsal root ganglion (DRG) neurons of rats after spinal cord injury (SCI).

METHODS: The rats were divided into 4 groups: control; sham control; SCI; and SCI+nimodipine groups. The neurons of the SCI groups were also incubated with non-specific TRPM2 channel blockers, 2-aminoethoxydiphenylborate (2-APB) and N-(p-amylcinnamoyl)anthranilic acid (ACA), before H2 O2 stimulation.

RESULTS: The [Ca(2+) ]i concentrations were higher in the SCI group than in the control groups, although their concentrations were decreased by nimodipine and 2-APB. The H2 O2 -induced TRPM2 current densities in patch-clamp experiments were decreased by ACA and 2-APB incubation. In the nimodipine group, the TRPM2 channels of neurons were not activated by H2 O2 or cumene hydroperoxide.

CONCLUSIONS: Increased Ca(2+) influx and currents in DRG neurons after spinal injury indicated TRPM2 and voltage-gated Ca(2+) channel activation.

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