JOURNAL ARTICLE

Solid-phase methodology for synthesis of O-alkylated aromatic oligoamide inhibitors of α-helix-mediated protein-protein interactions

Natasha S Murphy, Panchami Prabhakaran, Valeria Azzarito, Jeffrey P Plante, Michaele J Hardie, Colin A Kilner, Stuart L Warriner, Andrew J Wilson
Chemistry: a European Journal 2013 April 26, 19 (18): 5546-50
23508712
Rapid access to rigid rods: A method is described for the synthesis of 3-O-alkylated aromatic oligobenzamide foldamers that could be used for assembly of libraries of α-helix mimetic inhibitors of protein-protein interactions (see scheme; Fmoc=9-fluorenylmethoxycarbonyl).

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