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Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
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Fluorine-18 labeling by click chemistry: multiple probes in one pot.

Lina Jia, Zhen Cheng, Lingli Shi, Jianbo Li, Cheng Wang, Dawei Jiang, Wei Zhou, Hu Meng, Yujin Qi, Dengfeng Cheng, Lan Zhang
Applied Radiation and Isotopes 2013 May
Click chemistry has been widely applied in drug development including radiopharmaceuticals and has shown great advantages. Here we reported a novel strategy for rapid preparation of multiple (18)F labeled PET probes in one pot using the 'Click Reaction' of Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition of terminal alkynes and organic azides (CuAAC). Preliminary results showed its high efficiency and potential for speeding up the preclinical screening of PET probes.

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