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Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
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Single continuous wave laser induced photodynamic/plasmonic photothermal therapy using photosensitizer-functionalized gold nanostars.

Shouju Wang, Peng Huang, Liming Nie, Ruijun Xing, Dingbin Liu, Zhe Wang, Jing Lin, Shouhui Chen, Gang Niu, Guangming Lu, Xiaoyuan Chen
Advanced Materials 2013 June 12
Chlorin e6 conjugated gold nanostars (GNS-PEG-Ce6) are used to perform simultaneous photodynamic/plasmonic photothermal therapy (PDT/PPTT) upon single laser irradiation. The early-phase PDT effect is coordinated with the late-phase PPTT effect to obtain synergistic anticancer efficiency. The prepared GNS-PEG-Ce6 shows excellent water dispersibility, good biocompatibility, enhanced cellular uptake and remarkable anticancer efficiency upon irradiation in vivo.

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