Pericentral retinal degeneration deteriorates during pregnancies.

A 25-year-old pregnant woman complained of a transient decrease of vision in her left eye. No ring scotoma was described. During her second pregnancy at age 27, the patient noticed subtle ring scotomas in both eyes. During her third pregnancy at age 30, the scotomas enlarged. A grayish zone with a few small areas of pigmentation around the macula was seen bilaterally. At age 37, the retinal degeneration progressed slightly: results of visual function and electrophysiologic examinations revealed mild rod and cone dysfunction. We believe that this patient represents a rare case of deteriorating pericentral retinal degeneration during pregnancies.