[Aryl hydrocarbon receptor interacting protein gene and familial isolated pituitary adenomas]

Feng Cai, Yi-dan Zhang, Cong-xin Dai, Xiao-hai Liu, Ya-kun Yang, Yong Yao, Ren-zhi Wang
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae 2012, 34 (6): 640-4
Familial isolated pituitary adenoma (FIPA) is an autosomal dominant disease, characterized by low penetrance, early-onset disease, more invasive tumor growth, as well as somatotroph and lactotroph adenomas in most cases. It has been indicated that the aryl hydrocarbon receptor interacting protein (AIP) gene is a tumor suppressor gene. Many heterozygous mutations have been discovered in AIP in about 20% of FIPA families. However, the exact molecular mechanism by which its disfunction promotes tumorigenesis of pituitary is unclear.

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